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November 28 Rihanna - Russian RouletteAnd you can see my heart beating You can see it through my chest Said I’m terrified, but I’m not leaving I know that I must pass this test So just pull the trigger. August 24 The RoseSome say love, It is a river,
That drowns the tender ring, Some say love, It is a razor, That leads your soul to bleed, Some say love, It is a hunger, And endless aching need, I say love, It is a flower, And you, its only seed, It's the heart, Afraid of breaking, That never, Learns to dance, It's the dream, Afraid of waking, That never, Takes the chance, It's the one, Who won't be taken, Who cannot seem to be, And the soul, Afraid of dying, That never, Learns to live, And the night, Has been too lonely, And the road, Has been too long, And you feel, That road is only for the lucky and the strong, Just remember, In the winter, Far beneath, The bitter snow, Lies a seed, That with the sun's love, In the spring, Becomes a rose  August 16 BWO-you are NOT aloneAfter the rain
I could see you crying Suffer the pain Like a river drying After the rain You're hiding from the daylight Deep in a groove Only walls around you Nowhere to move The state I found you Deep in a groove Lonely in the cold night You're not alone You're not the only one who hurts You're not alone This is the moment of rebirth I've seen your heartache I feel the pain you hide inside You're not alone Come, let me hold you Castle of sand There were promises And future was planned You hang onto a castle of sand Suffering from stage fright You're not alone You're not the only one who hurts You're not alone This is the moment of rebirth I've seen your heartache I feel the pain you hide inside You're not alone I stand beside you And when you walk in the valley of darkness And when you feel you've been left on your own I will stand there and wait for it beside you I will guide you home Come on home July 02 MJ has gone — So has our childhood.MJ has gone away. He is eventualy free in the paradise from all the negative judgement from earthling. In a CBS interview clip, MJ was asked to address a few words to his fans and he stated as the following: "I would tell them I love them very much. And I— I— they've learned about me, and know about me from a distance. But if you really want to know about me, there's a song I wrote, which is the most honest song I've ever written. It's the most autobiographical song I've ever written". Here is that 'most' honest and autobiographical song ever writte from the bottom of his heart. I was so touched and saddened first time when I got the lyric. In contrast to the innocent song and voice, it reminds all the shit that he's been through, as well as the fact that we are all irreversibly getting aged..R.I.P. Michael,and to our past childhood but never faded.
Michael Jackson- Childhood
Have you seen my Childhood?
I'm searching for the world that I come from 'Cause I've been looking around In the lost and found of my heart No one understands me They view it as such strange eccentricities 'Cause I keep kidding around Like a child, but pardon me... People say I'm not okay 'Cause I love such elementary things It's been my fate to compensate, for the Childhood I've never known Have you seen my Childhood? I'm searching for that wonder in my youth Like pirates and adventurous dreams, Of conquest and kings on the throne... Before you judge me, try hard to love me, Look within your heart then ask, Have you seen my Childhood? People say I'm strange that way 'Cause I love such elementary things, It's been my fate to compensate, For the Childhood I've never known... Have you seen my Childhood? I'm searching for that wonder in my youth Like fantastical stories to share The dreams I would dare, watch me fly... Before you judge me, try hard to love me. The painful youth I've had Have you seen my Childhood? June 01 给十年后的我這十年來做過的事 能令你無悔 驕傲嗎 那時候你所相信的事 沒有被動搖吧 對象和緣份已出現 成就也還算不賴嗎 旅途上你增添了經歷 又有讓稜角 消失嗎 軟弱嗎 你成熟了 不會失去格調吧 當初堅持還在嗎 刀鋒不會 磨鈍了吧 老練嗎 你情願變得 聰明而不衝動嗎 但變成 步步停下三思 會累嗎 快樂嗎 你還是記得你跟我約定吧 區區幾場成敗裡 應該不致 麻木了吧 快樂嗎 你忘掉理想 只能忙於生活嗎 別太遲 又十年後至想 快樂嗎 April 15 寂寞拥挤在歡笑中掉淚 在呼吸中暈眩
在熱鬧中孤單 在人群中覺得累 凍得顫抖的夏天 寂寞擁擠的氣味 而我在回憶 捕捉失落的你 遺漏的章節 成為獨撐場面 青春劃成碎片 迴旋漫漫長街 愛的喘息如雷 我走遠 或許 我該道別 或許 如此最美 March 08 Sound of SilenceGreat songs will never fade. while I was watching Watchmen yesterday, this 40 year old song made my flesh creep, like a spark of light...
Hello darkness, my old friend
I've come to talk with you again Because a vision softly creeping Left its seeds while I was sleeping And the vision that was planted in my brain Still remains Within the sound of silence In restless dreams I walked alone Narrow streets of cobblestone 'Neath the halo of a street lamp I turned my collar to the cold and damp When my eyes were stabbed by the flash of a neon light That split the night And touched the sound of silence February 24 Beautiful Things - AndainNo one's calling for me at the door. And unpredictable won't bother anymore. And silently gets harder to ignore. Look straight ahead, there's nothing left to see. What's done is done, this life has got it's hold on me. Just let it go, what now can never be. I forgot that I might see, So many beautful things I forgot that I might need, to find out what life could bring. February 22 Stretch out your muscle Dr. Hermann Gaub talked about his current work on titin kinase stretching and single DNA assembly assay at this Thursday's symposium here at UIUC. They developed an experimental scheme where the AFM and TIRF microscopy were combined such that a nano-scaled pattern could be generated by arranging single fluorescently labeled DNA line after line using a AFM tip [1]. It looked kind of cool, but on second thougnt, i feel it seems no any application or question in reality would be addressed by this apparantly teeny fancy 'nanotechnique'. Contrarily, I am very into the titin kinase work, especially when he showed a movie zooming the human muscle into the molecular level step by step.
Biological responses to mechanical stress require strain-sensing molecules, whose mechanically induced conformational changes are relayed to signaling cascades mediating changes in cell and tissue properties. In vertebrate muscle, the giant elastic protein titin is involved in strain sensing via its C-terminal kinase domain (TK) at the sarcomeric M-band and contributes to the adaptation of muscle in response to changes in mechanical strain. TK is regulated in a unique dual autoinhibition mechanism by a C-terminal regulatory tail, blocking the ATP binding site, and tyrosine autoinhibition of the catalytic base. For access to the ATP binding site and phosphorylation of the autoinhibitory tyrosine, the C-terminal autoinhibitory tail needs to be removed. Here, we use AFM based single-molecule force spectroscopy, molecular dynamics simulations, and enzymatics to study the conformational changes during strain-induced activation of human TK. We show that mechanical strain activates ATP binding before unfolding of the structural titin domains, and that TK can thus act as a biological force sensor. Furthermore, we identify the steps in which the autoinhibition of TK is mechanically relieved at low forces, leading to binding of the cosubstrate ATP and priming the enzyme for subsequent autophosphorylation and substrate turnover. [2] February 15 后青春期的诗当烟雾随晨光飘散 枕畔的湖已风乾
期待已退化成等待 而我告别了突然 当泪痕勾勒成遗憾 回忆夸饰着伤感 逝水比喻 时光荏苒 终於 我们不再 为了生命狂欢 为爱情狂乱 然而青春彼岸 盛夏正要 一天 一天 一天的...灿烂 谁说不能让我 此生唯一自传 如同诗一般
无论多远未来 读来依然 一字 一句 一篇 都灿烂   |
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